Clinical Medicine and Nursing

Observation on Effect of 0.05% Cyclosporine Eye Drops Combined with 0.3% Sodium Hyaluronate Eye Drops on Dry Eyes after Cataract Surgery



Objective: to observe the curative effect of 0.05% cyclosporine eye drops combined with 0.3% sodium hyaluronate on dry eyes after cataract surgery. Methods: from June 2021 to September 2021, 78 patients (78 eyes) who underwent Phaco+IOL surgery in our hospital were diagnosed with dry eye after routine use of eye drops for one month. They were randomly divided into two groups according to the order of treatment, with 39 cases in each group. The control group used 0.3% sodium hyaluronate eye drops, while the observation group used 0.05% cyclosporine eye drops combined with 0.3% glass. Results: after treatment, BUT and SIt of the two groups were significantly longer than before treatment, while FL was significantly lower than before treatment. All indexes of the observation group combined with 0.05% cyclosporine eye drops were better, that is, BUT, SIt and FL were better, and the total effective rate of the observation group was significantly higher than that of the control group, with statistical significance (P<0.05). Conclusion: for dry eyes after cataract surgery, the application of 0.05% cyclosporine eye drops combined with 0.3 sodium hyaluronate eye drops has obvious curative effect, which is worth popularizing.


0.05% cyclosporine; 0.3% sodium hyaluronate; dry eyes after cataract surgery

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Ram J, Gupta A, Brar G, 2002. Outcomes ofphaeoemulsification impatients with dry eye. J CataractRefract Surg, 28(8):1386 1389.

China Branch of Asian Dry Eye Association, Eye Surface andTear Department of Ophthalmology Committee ofCross Strait Medical and Health Exchange Association, EyeSurface and Dry Eye Department of Ophthalmolog istsBranch of Chinese Medical Association. The consensus ofdry eye experts in China: Dry eye during cataract surgery inChina. Chinese Journal of Ophthalmology, 57(8):564 572.

Chuang J, et al., 2017. J Cataract Refract Surg, 43(12):1596 1607.

Liu Z G, Luo L H, Zhang Z P, 2002. Changes of tear film afterphacoemulsification. Chinese Journal of Ophthalmology, 38:274 277.

Xu W Q, Fei X F, Zhang J, et al., 2013. Treatment of dry eyewith sodium hyaluronate combined with recombinantbovine basic fibroblast growth factor afterphacoemulsification of diabetic cataract. China Journal ofPractical Ophthalmology, 31 (7): 844 888.

Department of Cornology, Ophthalmology Branch ofChinese Medical Association, 2013. Consensus of experts inclinical dia gnosis and treatment of dry eye. Chinese Journalof Ophthalmology, 49(1)73 75.

Liu Z G, Peng J, 2008. Diagnostic and therapeutic criteria ofdry eye. Ophthalmology Research. 3(26):161 164.

Macri A,Rolando MPflugfelder S, 2000. A standardizedvisua l scale for evaluation of tear fluoresecein clearance.Ophthalmology, 107:1338 1343.

China Branch of Asian Dry Eye Association, Ophthalmologyand Tear Department of Ophthalmology Committee ofCross Strait Medical and Health Exchange Association,Ophtha lmology Department of Ophthalmologists Branch ofChinese Medical Doctor Association,2020. China dry eyeexpert consensus: diagnosis and classification. ChineseJournal of Ophthalmology, 56(6):418 422.

Mencucci R, 2021. Ophthalmol Ther, 10(2): 211223.

Zhang C Z, 2016. Etiology, diagnosis and treatment of dryeye after cataract surgery. Armed Police Medicine, 27(2):201 203.

Oh T, 2012 Jpn J Ophthalmol 2012 Mar 56(2):113 118.

Li X M, Zhao X, Hu L Z, 2007. Clinical observation of dryeye s in cataract patients before and after surgery. ChineseJournal of Ophthalmology, 43(1):10 13.

Cetinkaya S , et 2015 BMC Ophthalmol 30 15 68.

Xue W, et al., 2019 Int Ophthalmol 39(2):419 429.

Iglesias E, et al., 2018 Cornea 37(7 ):893 898.

Liu Z G, Wang W, 2009. Surgeryrelated dry eye. ChineseJournal of Ophthalmology, 45:483 485.

Li W, 2021. Cataract and intraocular lens group ofophthalmology branch of Chinese medical association.Chinese Journal of Ophthalmology, 57( 1):17 22.

Gao J, et al.2013. Invest Ophthalmol Vis Sci, 54(7):4717 33.

Moon I, et al.2018. J Ocull Phamacol Ther, 34(9):612 620.

Chung Y W, et al.2013. Korean J Ophthalmol, 27(3):167 71.

Chen W F, Su J B, Ma Y M, et al.2016. Effect of QijuDihuang Pill assisted with sodium hyaluronate on visualfunction and tear film stability of patients with dry eye.International Journal of Ophthalmology, 16(3):505 507.

Hong X F, Chen Y, 2016. Clinical observation of differentconcentrations of sodium hyaluronate eye drops on dryeyes after cataract surgery. Zhejiang Clinical Medicine,18(10): 1836 1837.



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