临床医学与护理

孟德尔随机化在肿瘤研究中的应用现状与展望

孙颖 (泰安市中医医院), 常腾腾 (泰安市中医医院), 李磊 (泰安市中医医院), 胡照洋 (泰安市中心医院), 满敏 (泰安市中医医院)

摘要


孟德尔随机化作为一种基因流行病学分析方法，近年来在肿瘤治疗领域得到了广泛应用。它利用基因变异作为工具变量，评估暴露因素与疾病结果之间的因果关系。文章综述了孟德尔随机化在肿瘤治疗中的应用，包括其基本原理、优势及在不同肿瘤类型中的研究进展。通过孟德尔随机化方法，研究人员能够减少传统观察性研究中的偏倚，更好地识别潜在的治疗靶点，从而为肿瘤治疗提供新的视角和可能的干预策略。

关键词


孟德尔随机化；肿瘤治疗；因果推断；基因流行病学；工具变量

全文:

PDF

参考


杜凯豪,侯立朝,罗兰明慧,等.孟德尔随机化在胰腺癌研究中的应用现状与展望[J].临床肝胆病杂志,2024,40(10):2127-2136.

李增俊,林奕蝶,陈海畅,等.女性雌激素与乳腺癌发病和死亡风险因果关联的孟德尔随机化研究[J].现代预防医学,2024,51(6):1012-1016.

邢智轩,周洋洋,张家坤,等.双样本孟德尔随机化法探究出生体重与乳腺癌的关系[J].江苏预防医学,2022,33(2):119-123.

Lawler T. Warren Andersen S. Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies[J].Nutrients,2023,15(2):422.

Zhou W, Liu G, Hung RJ, Haycock PC, Aldrich MC, Andrew AS, Arnold SM, Bickeb?ller H, Bojesen SE, Brennan P, Brunnstr?m H, Melander O, Caporaso NE, Landi MT, Chen C, Goodman GE, Christiani DC, Cox A, Field JK, Johansson M, Kiemeney LA, Lam S, Lazarus P, Le Marchand L, Rennert G, Risch A, Schabath MB, Shete SS, Tardón A, Zienolddiny S, Shen H, Amos CI. Causal relationships between body mass index, smoking and lung cancer: Univariable and multivariable Mendelian randomization[J]. Int J Cancer,2021,148(5):1077-1086.

Zhou W, Liu G, Hung RJ, Haycock PC, Aldrich MC, Andrew AS, Arnold SM, Bickeb?ller H, Bojesen SE, Brennan P, Brunnstr?m H, Melander O, Caporaso NE, Landi MT, Chen C, Goodman GE, Christiani DC, Cox A, Field JK, Johansson M, Kiemeney LA, Lam S, Lazarus P, Le Marchand L, Rennert G, Risch A, Schabath MB, Shete SS, Tardón A, Zienolddiny S, Shen H, Amos CI. Causal relationships between body mass index, smoking and lung cancer: Univariable and multivariable Mendelian randomization[J]. Int J Cancer,2021,148(5):1077-1086.

Bull CJ, Bell JA, Murphy N, Sanderson E, Davey Smith G, Timpson NJ, Banbury BL, Albanes D, Berndt SI, Bézieau S, Bishop DT, Brenner H, Buchanan DD, Burnett-Hartman A, Casey G, Castellví-Bel S, Chan AT, Chang-Claude J, Cross AJ, de la Chapelle A, Figueiredo JC, Gallinger SJ, Gapstur SM, Giles GG, Gruber SB, Gsur A, Hampe J, Hampel H, Harrison TA, Hoffmeister M, Hsu L, Huang WY, Huyghe JR, Jenkins MA, Joshu CE, Keku TO, Kühn T, Kweon SS, Le Marchand L, Li CI, Li L, Lindblom A, Martín V, May AM, Milne RL, Moreno V, Newcomb PA, Offit K, Ogino S, Phipps AI, Platz EA, Potter JD, Qu C, Quirós JR, Rennert G, Riboli E, Sakoda LC, Schafmayer C, Schoen RE, Slattery ML, Tangen CM, Tsilidis KK, Ulrich CM, van Duijnhoven FJB, van Guelpen B, Visvanathan K, Vodicka P, Vodickova L, Wang H, White E, Wolk A, Woods MO, Wu AH, Campbell PT, Zheng W, Peters U, Vincent EE, Gunter MJ. Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study[J]. BMC Med,2020,18(1):396.




DOI: https://doi.org/10.33142/cmn.v2i2.14034

Refbacks

  • 当前没有refback。