自然科学研究

活体细菌在药物载体中的表面修饰策略

尹梓沣 (广西民族大学 海洋与生物技术学院), 苏小凌 (广西民族大学 海洋与生物技术学院), 王中灵 (广西民族大学 海洋与生物技术学院), 黄立明 (广西民族大学 海洋与生物技术学院), 樊芝伶 (广西民族大学 海洋与生物技术学院), 陈雨珊 (广西民族大学 海洋与生物技术学院), 彭敏童 (广西民族大学 海洋与生物技术学院), 廖艳娟 (广西民族大学 海洋与生物技术学院)

摘要


活体细菌因其独特的生物相容性、易于获取性及靶向输送能力，近年来成为药物载体研究的热点。活体细菌不仅能够有效地携带药物，还能通过其生物特性实现靶向治疗，从而提高疗效并减少副作用。随着生物医学技术的进步，对细菌表面进行修饰的研究逐渐增多，以期提升药物的递送效率和靶向性。当前，活体细菌的表面修饰主要包括化学修饰、基因工程修饰和物理修饰等多种方法，各种修饰技术各具优缺点，并在药物递送中展现出不同的应用潜力。然而，活体细菌作为药物载体的研究仍面临诸多挑战，如生物安全性、细菌的存活率及药物释放控制等问题。本论文旨在综述活体细菌作为药物载体的表面修饰现状，探讨其在未来药物递送中的应用前景，为相关领域的研究提供参考和启示。

关键词


活体细菌；药物载体；表面修饰；药物递送；靶向治疗

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参考


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DOI: https://doi.org/10.33142/nsr.v1i3.14909

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